Liver ascites

Ascites is most commonly associated with advanced liver disease, and is due to the replacement of healthy liver tissue with fibrous or scar tissue, called cirrhosis, which may cause fluid to leak from the liver and accumulate in the abdominal cavity.

Alcohol and viral hepatitis B and C are common causes of cirrhosis, although there are many other causes including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatis (NASH). NASH is a “silent disease”, which means it is difficult to diagnose until the disease is significantly developed and therefore intervention at an early stage to prevent the fibrosis and scarring is clinically challenging. The incidence of liver disease and liver cirrhosis is increasing driven by unhealthy lifestyles, obesity and ageing populations.

Liver ascites forms as the result of a sequence of events which are usually asymptomatic. Following the development of scar tissue within the liver, portal hypertension is likely occur. As portal hypertension develops, various biological factors will tend to over come the apparition of portal hypertension with the release locally of vasodilators. A chain of cascades will follow affecting the splanchnic blood flow and arterial pressures, which will results activation of different other mechanisms and resulting in sodium and water retention.

Approximately 50% of cirrhotic patients develop ascites within 10 years of the diagnosis of cirrhosis

We would like to use cookies to better understand your use of this website. This enables us to improve your future experience on our website. Detailed information about the use of cookies on this website and how you can manage or withdraw your consent at any time can be found in our
Privacy & Cookie Policy

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.